The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Since the dawn of civilization, humans have wondered who or what created the universe. Religion offers a spiritual answer, but do the latest discoveries in physics show evidence of a transcendent intelligence, or simply that the laws of physics by themselves could have led to the universe in which we live? This episode embarks on a mind-bending scientific search for God, asking physicists and theologians if the seemingly miraculous way the universe has been calibrated to support life is evidence of a creator...whether string theory will eventually be able to rule out the existence of God...why Stephen Hawking says the universe could have been created spontaneously...and how an advanced civilization in another universe could have conceivably created our own.

Atheist and scientist Richard Dawkins visits England, America and Israel interveiwing prominant people of faith; Islamic, Hasidic Jews, and the new Christian sects popping up throughout the world, and expressing his view of the extent to which this fanaticism has degraded our civilisation, and will continue to degrade it. "The God Delusion" explores the unproven beliefs that are treated as factual by many religions and the extremes to which some followers have taken them. Dawkins opens the programme by describing the "would-be murderers ... who want to kill you and me, and themselves, because they're motivated by what they think is the highest ideal." Dawkins argues that "the process of non-thinking called faith" is not a way of understanding the world, but instead stands in fundamental opposition to modern science and the scientific method, and is divisive and dangerous.

After 400 BC, a new philosophy was born in South east Asia, generated from the ideas of Buddha, a mysterious Prince from India who gained enlightenment while he sat under a large, shapely fig tree. He remains one of the most legendary and influential of all religious progenitors, but what of his actual life? In this biographical documentary, director David Grubin tells the historical tale of Gautama Buddha (563-483 BC), from his initial enlightenment through his death around the age of 80. In the process, Grubin makes an unusual point: that Gautama never once claimed to be God or God's emissary, but instead sought to find a way to bring peace and alleviation from suffering to others in a cruel and often insane world. In telling this story, Grubin combines a number of elements including original animations, testimony by contemporary Buddhists such as the 14th Dalai Lama Tenzin Gyatso, glimpses of sculptures and paintings that help tell Gautama's story, and much more. Narrated by Richard Gere

Diarmaid MacCulloch's own life story makes him a symbol of a distinctive feature about Western Christianity - scepticism, a tendency to doubt which has transformed both Western culture and Christianity. In the final programme in the series, he asks where that change came from. He challenges the simplistic notion that faith in Christianity has steadily ebbed away before the relentless advance of science, reason and progress, and shows instead how the tide of faith perversely flows back in. Despite the attacks of Newton, Voltaire, the French Revolutionaries and Darwin, Christianity has shown a remarkable resilience. The greatest damage to Christianity was actually inflicted to its moral credibility by the two great wars of the 20th century and by its entanglement with Fascism and Nazism. And yet it is during crisis that the Church has rediscovered deep and enduring truths about itself, which may even be a clue to its future.

Seven years have passed since Antony's departure from Rome, and the former commander, dissipated and debauched - held in thrall by the charms and sexual prowess of his new bride, Cleopatra, withholds precious shipments of grain from Rome, where people die in the streets from hunger.
Unable to incite a war with Antony and Egypt without committing political suicide, Octavian sends Atia and Octavia to Alexandria to mediate and reason with Antony; a strategy which proves predictably unsuccessful.